Environmental Aspects • The global chemical management system was upgraded in fiscal 2021 to improve the risk assessment accuracy for chemicals used across the Group. The system is now used as a database not only to reduce risks but also to develop technologies that contribute to solving social issues. • In fiscal 2022, we enhanced an existing system to manage chemicals contained in molded items to enable speedy and highly accurate risk assessment of our various products, some of which comprise numerous components that could reach even tens of thousands. Classification and Standards of Chemical Substances in Molded Items Classifications of Chemical Substances Management Details Restricted containing chemical Chemical substances are prohibited or limited to use in molded items by laws substances or the Company’s regulations. Content monitored/managed chemical Chemical substances whose content in molded items must be monitored and substances managed. 3.6.3 Promoting Alternatives to Animal Testing To reduce animal testing in the safety evaluation of chemicals, the Fujifilm Group is actively developing alternative methods for skin sensitization testing, skin irritation testing, etc. as well as participating in joint studies on alternative methods. Targets and results Targets: Adopting alternatives to animal testing in all safety assessments. Conduct all the safety evaluation as alternatives to animal testing. (1) Conduct the safety evaluation for our newly developed chemicals using alternative methods for animal testing by FY2025*1. (2) Obtain the safety data on the safety data sheet for our chemical products using alternative methods for animal testing by FY2030*2. Results: “Amino acid Derivative Reactivity Assay (ADRA),” exclusively developed by Fujifilm, is a skin sensitization method that does not require animal testing. It enables a more accurate skin sensitization test compared with conventional methods, because we utilize advanced chemical synthesis and molecular design technologies. ADRA was adopted in the OECD test guidelines in 2019, and is now globally recognized as a standard testing method. In 2022, we developed the evaluation method “ADRA” that can evaluate not only single chemical but also mixtures, and was newly adopted in the OECD test guidelines (OECD TG 442C). We are now considering to apply this method to chemical substances we develop in the future. We introduced a new evaluation method that uses a Reconstructed Human Epidermis model for skin irritation tests on the chemicals used as raw materials in our products to ensure the safety of the employees involved. We are also working to adopt it in product testing. *1 We haven’t already tested with animals for safety evaluation of chemicals used in cosmetics (including quasi-pharmaceutical products). We do not plan to conduct animal testing for this purpose unless such testing is required to achieve accountability of chemical safety or is instructed by the authorities concerned. Note that we conduct legally specified safety evaluation for chemical substances used in medicines and foods. *2 C hemical products: Fine chemicals, various treatment chemicals, chemicals or mixture. 3.6.4 Contribute to Resolving Social Issues through Development of New Materials and Processes The Fujifilm Group is committed to using our core technology of materials and process development to provide products and services that resolve various social issues. Targets and results Target: Contribute to resolving social issues through development of new materials and processes. Result: Disclose our exclusive materials and processes developed by our Group to contribute SDGs. 93 FUJIFILM Holdings Corporation Sustainability Report 2023