OUR PURPOSE PIONEERING SCIENCE PATIENTS OUR PEOPLE ENVIRONMENT COMMUNITY REPORTING 53 BIOGEN 2021 YEAR IN REVIEW Working at the intersection of technology and well-being Neurological diseases are highly complex and devastating, and there are still significant challenges in how we understand and treat them. Today’s technological advances open a new era of opportunities for digital health in neuroscience. Powered by data science and digital technologies, we’re driving solutions to advance research, clinical care and patient empowerment. Our Digital Health Team is made up of diverse talent investigating how technology can improve drug development through personalized medicine evidence, and developing digital health, digital medicine and digital therapeutics solutions that transform patients’ lives. Below are some examples of our digital health work. Launched pioneering cognitive health study, using Apple Watch and iPhone In 2021, we launched a new virtual research study, Intuition, in collaboration with Apple, that is investigating the role Apple Watch and the iPhone could play in developing digital biomarkers to monitor cognitive performance and screening for decline in cognitive health. This includes potentially detecting mild cognitive impairment (MCI), an early indicator of certain forms of dementia such as Alzheimer’s disease. The multi-year, observational study includes 23,000 participants of different ages (21-86), genders, races, ethnicities and education levels, with a range of cognitive performance. The successful development of digital biomarkers in brain health would help address the significant need to accelerate patient diagnoses and empower physicians and individuals to take timely action. For healthcare systems, such advancements in cognitive biomarkers from large-scale studies could contribute significantly to prevention, better population- based health outcomes, and lower costs to health systems. BrainGuide™ addresses need for brain health information Created by UsAgainstAlzheimer’s based on input from medical experts, with in-kind and financial support from Biogen, BrainGuide provides a way for individuals who are concerned about their own or a loved one’s brain health to receive tailored information based on responses to a confidential memory questionnaire. As BrainGuide marked its first birthday in March 2022, it celebrated that over 160,000 people had used the free memory questionnaire for tailored resources. BrainGuide’s platform runs on Amazon Web Services (AWS), using state-of-the-art technologies to power the free memory questionnaire capability and to make it available to anyone with telephone or internet access. This platform aims to increase brain health awareness and empower people with next best actions by providing educational resources in both English and Spanish. Patient Advocacy Groups were also instrumental in driving awareness about Biogen’s Intuition Study. Many of the PAGs announced the study to their members and in November, we held a symposium at Healthy Churches 2030 titled “Brain Health & Wellness: The Role of Technology,” an interactive and informative session about harnessing the power of technology to support the cognitive health of African Americans. Sharing advice with promising digital health start-ups In 2021, Biogen organized an Alzheimer’s Disease Challenge workshop at the world’s leading startup conference, Slush, in Helsinki, Finland. We aim to support digital health startups with commercialization and implementation plans for prevention and early detection of Alzheimer’s disease, patient and caregiver support, and healthcare system support in Alzheimer’s disease management. More than 50 startups across Europe applied, and nine were invited to attend and work with the Biogen team, leading external experts representing healthcare and research organizations, and the Alzheimer’s disease patient community. The three-hour event provided the startups with concrete advice on questions related to market-entry model, evidence creation and addressable gaps in the Alzheimer’s disease ecosystem. Biogen is committed to lending our expertise and working with others to help patients and caregivers impacted by Alzheimer’s disease.