OUR PURPOSE PIONEERING SCIENCE 133 GRI CONTENT INDEX BIOGEN 2021 YEAR IN REVIEW PATIENTS OUR PEOPLE ENVIRONMENT COMMUNITY REPORTING GRI indicator Reporting Requirements 2021 Response Alignment SDG 102–10 Significant changes to the organization’s size, structure, ownership, or supply chain, including: • Changes in the location of, or changes in, operations, including facility openings, closings and expansions. • Changes in the share capital structure and other capital formation, maintenance and alteration operations (for private sector organizations). • Changes in the location of suppliers, the structure of the supply chain, or relationships with suppliers, including selection and termination. Item 1., Business, 2021 Annual Report 102–11 Whether and how the organization applies the Precautionary Principle or approach. Biogen applies the precautionary principle through a variety of environment, health and safety (EHS) and risk management policies and programs designed to ensure the safety of products, patients, employees and the environment. Details are available in Annual Report and on Biogen.com 102–12 A list of externally-developed economic, environmental and social charters, principles or other initiatives to which the organization subscribes, or which it endorses. Principles, Policies and Positions Code of Business Conduct All major charters, principles or other initiatives are included in the boundaries of this report 102–13 A list of the main memberships of industry or other associations, and national or international advocacy organizations. Community and Reporting – 2021 Year in Review Strategy 102–14 A statement from the most senior decision-maker of the organization (such as CEO, chair, or equivalent senior position) about the relevance of sustainability to the organization and its strategy for addressing sustainability. CEO Letter – 2021 Year in Review 102–15 A description of key impacts, risks and opportunities. Item 1A., Risk Factors, 2021 Annual Report TCFD Report – 2021 Year in Review * Ethics and Integrity 102–16 A description of the organization’s values, principles, standards and norms of behavior. Principles, Policies and Positions Code of Business Conduct Our Purpose – 2021 Year in Review 102–17 A description of internal and external mechanisms for: • Seeking advice about ethical and lawful behavior, and organizational integrity. • Reporting concerns about unethical or unlawful behavior, and organizational integrity. Code of Business Conduct * Governance 102–18 a. Governance structure of the organization, including committees of the highest governance body. b. Committees responsible for decision-making on economic, environmental and social topics. Executive Leadership Board of Directors Corporate Governance Documents ESG Data Table – 2021 Year in Review