OUR PURPOSE PIONEERING SCIENCE COMMUNITY REPORTING 94 BIOGEN 2021 YEAR IN REVIEW PATIENTS OUR PEOPLE ENVIRONMENT Reducing waste Manufacturing medicines typically generates a large amount of waste relative to the amount of product produced. Minimizing waste reduces environmental impacts and disposal costs, and also results in more cost-effective production of medicines through a lower cost of goods. In 2021, the MIT Sloan School of Management’s Health Lab (MIT H-Lab) presented findings from a targeted assessment of ways Biogen can reduce the use of plastics (see targets above) and created a strategic environmental sustainability framework to assess the impact of key product lines. This exercise is only one part of Biogen’s larger sustainability commitment. Biogen has applied metrics with targets to all our manufacturing processes to track how much waste our processes generate. We continue to advance our waste-reduction targets and to sustain our zero waste to landfill goal, established in 2014. From 2019 to 2021, we cut in half the total waste generated from our operations. In 2021, we also sustained 100% diversion of waste from landfill. This includes vials, boxes, pens, auto-injectables and leaflets, 43% of which are associated with product packaging and can be recycled. In the U.S., we also collect all unused products and used sharps. Environmental health and safety (EHS) systems Our EHS management system is implemented in line with recognized international standards, including ISO 14001, 18001 and 50001. Every three years, we have our management system externally audited to ensure our system remains in line with evolving expectations. Our North Carolina sites continue to maintain their Carolina Star certification, and we may move forward with externally certifying our Solothurn biologics manufacturing facility to ISO 14001 and/or 50001 in the future. Our goal is to foster a culture of sustainable collaboration internally and externally, facilitating the sharing of ideas, strategies, tools and improvements toward our vision of a more healthy, equitable and sustainable world. From 2019 to 2021, WE CUT IN HALF the total waste generated from our operations In 2021, we achieved a 99.9% diversion of waste from landfill Every stage a product passes through – from development to patient use to disposal – presents opportunities for and challenges to sustainability.” Laurent Dionet Senior Engineer on Biogen’s packaging team