Worldwide Prescription Drug & OTC part 1 of 2 Sales by Technology (2010-2024) Biotech product sales overtake conventional product sales in the sixth largest seller of biotech products in 2024, mostly driven by top 100 product by sales for the 昀椀rst time. Merck & Co is forecast an increase in Trulicity forecast. Merck & Co, with a CAGR of 10.9%, to climb to second position after Roche in biotech sales. is forecast to be the best performer in the next six years gaining The industry uptake of biotech products is forecast to rise from 28% 昀椀ve positions in the ranking from 2018. AbbVie has the lowest to 32% between 2018 and 2024. In contrast, the top 100 product CAGR (-4.9%) of the top 10 companies, primarily due to Humira’s sales share of biotech and conventional products is forecast to patent expiry. stabilise around a 50/50 split in 2024. Eli Lilly is set to become the Figure 4: Worldwide Prescription Drug & OTC Pharmaceutical Sales: Biotech vs. Conventional Technology Source: EvaluatePharma, May 2019 90% 82% 82% 80% 79% 78% 77% 80% 75% 74% 72% 71% 70% 70% 69% 69% 68% 70% 60% Biotech Products Within Top 100 50% 34% Rapid increase in share of Top 100 products: 2024 Split: 66% - 2010: 34% 47% 53% Biotech: n=50 (avg. $4.1bn) 50% 50% 40% - 2018: 53% Conv.: n=50 (avg. $3.2bn) - 2024: 50% 30% 29% 30% 30% 31% 31% 32% 20% 26% 28% 21% 22% 23% 25% Technology % of Prescription & OTC Sales10%18%18%20% 0% 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 Biotechnology Conventional/Unclassified Table 4: Worldwide Prescription Drug & OTC Sales by Technology (2010-2024) Source: EvaluatePharma, May 2019 Technology 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 Biotechnology 18% 18% 20% 21% 22% 23% 25% 26% 28% 29% 30% 30% 31% 31% 32% Conventional/Unclassi昀椀ed 82% 82% 80% 79% 78% 77% 75% 74% 72% 71% 70% 70% 69% 69% 68% Total Prescription & OTC Sales 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% WW Sales ($bn) Technology 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 Biotechnology 129 140 151 163 176 181 199 217 243 258 277 300 327 356 388 Conventional 439 463 441 433 444 438 443 444 455 455 478 511 547 584 626 Other Unclassi昀椀ed Sales 154 169 166 173 174 163 166 164 165 166 174 182 191 200 209 Total Prescription & OTC Sales 722 771 758 769 794 782 808 825 864 880 929 992 1065 1140 1222 ® 12 EvaluatePharma World Preview 2019 Copyright © 2019 Evaluate Ltd. All rights reserved.