Responding to the opioid epidemic in the U.S. Each day, our distribution teams deliver lifesaving medicines to pharmacies, hospitals and clinics that serve millions of Americans. We carefully deliver products to our customers for their patients in need. We know there’s a patient behind every package. Over the past decade, as the opioid epidemic evolved rapidly, we enhanced our teams, processes and technologies dedicated to preventing diversion. We are committed to maintaining — and continuously enhancing — strong programs designed to detect and prevent opioid diversion within the pharmaceutical supply chain, while also protecting the availability of appropriate treatments for patients with serious illnesses and injuries. We remain committed to engaging with all who share our dedication to act with urgency to address this epidemic and work together to end this national crisis. Community investment: reducing the burden of cancer The vision of the McKesson Foundation is to help ensure that everyone has access to high-quality healthcare. We believe in partnering with nonprofit organizations and key community stakeholders to understand the needs of the communities where we live and work, leveraging the talent and resources of McKesson to make a meaningful difference. In FY21, we partnered with the American Cancer Society and the Canadian Cancer Society as part of our commitment to reducing the burden of cancer. Under this focus area, we invested $121,000 to cancer-focused nonprofit organizations throughout the U.S. and Canada as a part of McKesson’s annual Community Days volunteer event. In Canada, we also donated more than $25,000 to the Terry Fox Foundation as part of the annual McKesson in Motion Challenge. In-kind contributions Each month, McKesson’s Medical-Surgical team works with World Vision, a nonprofit organization that tackles the causes of poverty and injustice, to provide in-kind contributions that are then distributed by the organization to places in need. Through our partnership with World Vision, McKesson’s Medical- Surgical business donated 730 pallets, totaling more than 625 tons, of medical supplies during FY21. Donated items included: • United States: Personal care, medical supplies, and surgical kits • Central America: Adult diapers, medical supplies, furniture, apparel, walkers, crutches, and wheelchairs • Africa: Adult diapers, surgical clean-up kits, medical supplies, and medical and office furniture • Middle East: OB-GYN essentials We invested $121,000 to cancer-focused nonprofit organizations throughout the U.S. and Canada as a part of McKesson’s annual Community Days volunteer event. Introduction Stories Employees Access Equity Climate Operations >Table of Contents | 31 FY21 Impact Report

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