GRI disclosure GRI requested information McKesson FY21 response/ disclosure location Reporting practice 102-46 Defining report content and topic boundaries A new approach to strategically investing in our communities, pgs. 14-15 McKesson at a glance, pg. 6 ESG governance, pgs. 56-57 102-47 List of material topics We have included all of the topics covered in our FY20 report. 102-48 Restatements of information We restated our FY20 water use data to align reporting boundaries across FY20 and FY21. 102-49 Changes in reporting Our greenhouse gas and water boundary now includes data from the US Oncology Network 102-50 Reporting period April 1, 2020 – March 31, 2021 (McKesson’s FY21) 102-51 Data of most recent report November 2020 102-52 Reporting cycle We report annually 102-53 Contact point for questions regarding report Please direct questions to: [email protected] 102-54 Claims of reporting in accordance with GRI Standards This report has been prepared with reference to the GRI Standards: Core Option 102-55 GRI Content Index This table constitutes our GRI Content Index 102-56 External assurance We plan to pursue external assurance for some ESG topics in future reports. GRI disclosure GRI requested information McKesson FY21 response/ disclosure location 201: Economic performance 103-1 Explanation of the material topic and its boundaries McKesson at a glance, pg. 6 103-2 The management approach and its components McKesson at a glance, pg. 6 103-3 Evaluation of the management approach McKesson at a glance, pg. 6 201-1 Direct economic value generated and distributed Annual Report and Form 10-K contain details on our FY21 annual revenues of $238 billion. 201-2 Financial implications and other risks and opportunities due to climate change Climate change: risks and opportunities pg. 38 McKesson’s approach to climate change, pgs. 39-43 2021 CDP Climate Change Response Form 10-K , pgs. 13, 24 203: Indirect economic impacts 103-1 Explanation of the material topic and its boundaries McKesson at a glance, pg. 6 103-2 The management approach and its components Culture, pgs. 19-23 Caring for our communities, pgs. 24-26 , 30-31 , 48-50 Addressing waste, pgs. 44-46 Supply chain integrity, pgs. 62-65 103-3 Evaluation of the management approach A new approach to strategically investing in our communities, pgs. 14-15 203-1 Infrastructure investments and services supported Caring for our communities, pgs. 24-26 , 30-31 , 48-50 Addressing waste, pgs. 44-46 Supply chain integrity, pgs. 62-65 Introduction Stories Employees Access Equity Climate Operations >Table of Contents | 73 FY21 Impact Report

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