2021 CORPORATE RESPONSIBILITY REPORT I 27 Trends ® 1 1. . The COVID - 19 pandemic worsened the drug crisis and physicians anticipate a continuing rise in overdose deaths 2 2 . . Physicians worry they have missed signs of drug misuse and use disorders during the pandemic and express concerns about telehealth Based on a first-of-its-kind study conducted by Quest Diagnostics, the Health Trends report Drug Misuse in America 2021 1 examines the contributing factors to the significant increase in overdose deaths seen during the pandemic and provides insights on barriers health professionals face in their ability to monitor and intervene with their patients at risk for drug misuse. 1 Key findings from the report include 1 : • The pandemic worsened the drug crisis, and physicians anticipate a continuing rise in overdose deaths • Physicians worry that they have missed signs of drug misuse during the pandemic and express concerns about recognizing signs of drug misuse during telehealth sessions • Physicians fear that illicit fentanyl will claim more lives than prescribed opioids • Despite physician confidence in counseling patients, nearly half of tested patients show drug misuse • Clinical drug testing is deemed critical, but clearer guidelines would help optimize its use “Clinical drug testing gives physicians the ability to uncover insights into problematic drug use before the worst outcomes can occur. [Although] our research shows that physicians overwhelmingly value clinical drug testing in patient management... there remains an unmet need for clear clinical guidelines regarding when and how to test, which tests to use, and the frequency of testing.” Jeffrey Gudin, MD Senior Medical Advisor, Drug Monitoring and Toxicology 1 Health Trends ® Drug Misuse in America 2021 Physician Perspectives and Diagnostic Insights on the Drug Crisis and COVID-19 November 2021 3 3 . . Physicians are prescribing more gabapentin than opioids for chronic pain and worry patients will turn to illicit fentanyl 4 4 . . Despite physician confidence in counseling patients, nearly half of tested patients show drug misuse 5 5. . Clinical drug testing is deemed critical, but clearer guidelines would help optimize its us e Quest, Quest Diagnostics, any associated logos , and all associated Quest Diagnostics registered or unregistered trademarks are the property of Quest Diagnostics. All third-par ty marks— ® and ™— are the property of their respective owners. © 2021 Quest Diagnostics Incorporated. A ll rights reserved. MI10758 11/2021 Key insights on current and emerging healthcare issues (continued) Physicians worry about missing signs of drug misuse and fear fentanyl will be deadlier than opioids TABLE OF CONTENTS 2021 OVERVIEW COVID-19 RESPONSE PROMOTING A HEALTHIER WORLD CREATING AN INSPIRING WORKPLACE BUILDING VALUE REFERENCES