Zimmer Biomet conducts studies all over the world that are managed by our global Clinical Affairs teams. These teams manage our regulated and post-market studies and are located in key locations across the globe. In all instances, these programs and teams adhere to Zimmer Biomet policies and procedures that incorporate the standards set forth in the International Conference on Harmonization, the Declaration of Helsinki, Good Clinical Practice guidelines and the AdvaMed Code of Ethics. To protect the rights, privacy, safety and well-being of clinical trial participants, Zimmer Biomet has an overarching global procedure for Conducting Clinical Research Involving Human Subjects. This procedure also ensures that the clinical research from our clinical trials is qualified and reliable and can be used by worldwide regulatory authorities. As part of our procedures, clinical trials are reviewed and approved by several cross-functional internal committees, including a Clinical Investigation Review Committee and a Clinical Research Review Committee. Clinical trials are only approved if they are scientifically sound, meet a well-defined business need and are within fair market value calculations. Clinical trial support can range from monetary funding, providing in-kind product, or even the loaning of specialized instrumentation and equipment. In addition to the internal Zimmer Biomet review and approval processes, all clinical studies are required to be reviewed and approved by an Institutional Review Board or Ethics Committee that is independent of both Zimmer Biomet and the participating investigational centers. Clinical Trial Transparency Zimmer Biomet supports clinical research to foster advances in clinical knowledge and furthering medical device development related to our products and programs. As such, clinical trial transparency is required to appropriately contribute to and comply with the International Committee of Medical Journal Editors (ICMJE) initiative and Food and Drug Administration Amendments Act (FDA A A) requirements by utilizing ClinicalTrials.gov to register our active clinical studies and study results once they are available. All study results are posted, regardless of whether the trial is deemed successful or failed to meet the primary end point. A sample listing of Zimmer Biomet clinical trials can be found at ClinicalTrials.gov . Grants, Donations and Funding Zimmer Biomet Foundation Zimmer Biomet is committed to our guiding principle of giving back to our communities and people in need. The Zimmer Biomet Foundation is an independent, philanthropic, nonprofit organization established in 2018 to address the needs of our global community. The mission of the Zimmer Biomet Foundation is to improve the quality of life for our communities by providing resources to help: build healthy communities, advance Science, Technology, Engineering and Math (STEM) education, provide disaster relief and address healthcare disparities while advancing diversity, equity and inclusion. Zimmer Biomet continued to fund the Zimmer Biomet Foundation with a large contribution in 2021, allowing for continued charitable work globally. From supporting Zimmer Biomet team members’ charitable programs, to funding community efforts in line with its pillars, the Zimmer Biomet Foundation donated nearly $2.7 million in charitable grants in 2021. The Zimmer Biomet Foundation continued the Team Member Relief Fund to support team members facing financial hardship due to personal or catastrophic reasons, including COVID-19. Since its inception, the Fund has provided more than $1 million in relief grants to team members. 14