Accelerated innovation is paving the way for a new normal Achieving agility with patient-centric design and the right technological infrastructure Pre-COVID Post-COVID Complex, inflexible protocols Protocol simplification Protocols that reduce patient burden and have built-in option to incorporateremote study approaches; leverage common protocols on basket studies Primarily on-site operations Remote site monitoring/source data verification and remote visits Shift towards remote Site selection and initiation visits with remote site support and increasedhybrid of onsite/remote (at home) patient visits Traditional randomized trials Novel trial design/hybridization of studies Master/Platform protocols, real world comparator arms, merging of real world modalities and early phase engagement and planning Digitization of study procedures Site-based study procedures Further evolution of digital patient options for clinical trial data collection such as ePRO, vitals, spirometry, ocular exam, ECGs, glucose monitoring, oximetry, etc. Limited patient communication Digital patient engagement Increased use of digital communications to keep patients informed and engaged while reducing burden and increasing retention IQVIA Global Executive Briefing: COVID-19 June 2020; Copyright 2020 IQVIA. 19