Patch Placement Tracker

NEUPRO is a prescription medicine used to treat Parkinson’s disease and moderate-to-severe primary Restless Legs Syndrome. NEUPRO Patch Placement Tracker Before applying the patch, please read the Patient Information and Instructions for Use provided with your NEUPRO prescription or on NEUPRO.com. The NEUPRO Patch is worn for 24 hours. Apply the patch to a different area of the skin each day for 14 days. Once you establish a 14-day pattern, follow the same pattern for each 2-week period. Use the Body Map, below, to track where you place the patch each day. Write the number “1” by the map location that corresponds to where you place the patch on Day 1, a number “2” by your Day 2 location, and so on. If you have any difficulty applying the NEUPRO Patch, please call our toll-free help line at 1-844-599-2273. R L R L FRONT SIDE BACK Please visit www.NEUPRO.com to: • Watch a video about how to apply the NEUPRO Patch • See if you qualify to save on NEUPRO • Learn more about the NEUPRO Patch Please see Important Safety Information on the reverse side.

Indication NEUPRO is a prescription medicine used to treat Parkinson’s disease and moderate-to-severe primary Restless Legs Syndrome. Important Safety Information NEUPRO contains a sulfite called sodium metabisulfite. Sulfites can cause severe allergic reactions that are life threatening to some people who are sensitive to sulfites. People with asthma are more sensitive to sulfites. Remove the patch right away and call your doctor if you have swelling of the lips or tongue, chest pain, or trouble breathing or swallowing. NEUPRO may make you fall asleep suddenly or without warning while doing normal activities, such as driving, which may result in accidents. Tell your doctor right away if this happens. Drinking alcohol or taking other medicines that cause drowsiness may increase your chances of becoming sleepy while using NEUPRO. Do not drive, use hazardous machinery, or do other dangerous activities until you know how NEUPRO affects you. NEUPRO can cause or worsen psychotic symptoms including hallucinations (seeing or hearing things that are not real), confusion, excessive suspicion, aggressive behavior, agitation, delusional beliefs (believing things that are not real), and disorganized thinking. The chances of having hallucinations or these other psychotic-like changes are higher in people with Parkinson’s disease who are elderly, taking NEUPRO, or taking higher doses of NEUPRO. If you have any of these problems, talk to your doctor. NEUPRO can cause decreases in blood pressure, especially when you start or increase your dose. Increases in blood pressure and heart rate, fainting, weight gain, and fluid retention also can occur. If you faint or feel dizzy, nauseated, or sweaty when you stand up from sitting or lying down, or have an unusually fast increase in weight, swelling, or fluid retention, especially in the ankles or legs, tell your doctor. Some patients using NEUPRO get urges to behave in a way that is unusual for them, such as unusual urges to gamble, strong urges to spend money, binge eating, or increased sexual urges and behaviors. If you or your family notices you are developing any unusual behaviors, talk to your doctor. NEUPRO may cause uncontrolled, sudden movements or make such movements you already have worse or more frequent if you have Parkinson’s disease, which may mean that your anti-Parkinson’s medicine needs to be changed. NEUPRO also may cause Restless Legs Syndrome symptoms to come back (rebound), become worse, or start earlier in the day. Skin reactions may occur at the site where you apply NEUPRO. Tell your doctor if you get a rash, redness, swelling, or itching that will not go away. Some people with Parkinson’s disease may have an increased chance of getting a skin cancer called melanoma. You should have your skin checked by a doctor regularly. Avoid exposing the NEUPRO patch you are wearing to heating pads, electric blankets, heat lamps, saunas, hot tubs, heated water beds, and direct sunlight. Too much medicine could be absorbed into your body. Also, do not wear NEUPRO during medical procedures called magnetic resonance imaging (MRI) or cardioversion because this could cause skin burns. Tell your doctor if you have breathing problems, a sleep disorder, mental problems, high or low blood pressure, or heart problems; are pregnant or plan to become pregnant; or are breastfeeding or plan to breastfeed. NEUPRO may not be right for you. The most common side effects in people taking NEUPRO for Parkinson’s disease are nausea, vomiting, sleepiness, application site reactions, dizziness, loss of appetite, difficulty falling asleep and staying asleep, increased sweating, vision problems, leg swelling, and uncontrolled, sudden movements of the arms or legs. The most common side effects in people taking NEUPRO for Restless Legs Syndrome are application site reactions, nausea, difficulty falling asleep and staying asleep, sleepiness, and headache. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088. ® NEUPRO is a registered trademark of the UCB Group of Companies. ©2015 UCB, Inc., Smyrna, GA 30080. All rights reserved. USP-NA-0515-00027