Introduction 29 2021 Sustainability Report A Modern, High-Performing Health System Our People and Culture Environmental Health Responsible Business Practices Performance Data Medication management is a critical part of caring for people with complex or chronic conditions, as they often require multiple drugs or treatments for rare diseases. To help consumers manage complex medication regimens, our personalized multidose packaging solutions support adherence and better health outcomes. These solutions are integrated into Optum Rx’s home delivery operations and have seen a meaningful increase in medication adherence. For people prescribed high-cost medications for complex conditions, such as cancer and diabetes, our specialty pharmacy business provides access to limited- distribution drugs, a supportive care provider experience and disease-area expertise. Through Optum Infusion Pharmacy, our network of more than 1,100 nurses delivers infusion therapy in patient homes as well as community infusion suites, providing patients with easier, more convenient access to therapies that typically treat chronic or serious disease. We use advanced analytics to ensure drugs are administered at the most appropriate and cost-effective site of care. Home delivery outcomes for consumers taking multiple medications ~90% adherence rates for 30-day prescriptions compared to 60%-70% at retail pharmacies. 12% higher NPS. 17% higher savings compared to retail. Our commitment Close 600 million gaps in care for our members by the end of 2025. In 2021, we closed approximately 110 million gaps in care toward our commitment to close 600 million gaps from 2021 through 2025. Overall gap closure rates were impacted by the reduced level of preventive care during the pandemic. We worked to mitigate this by increasing in-home visits and member outreach activities. The 600 million gap closure target was based on the 2019 Healthcare Effectiveness Data and Information Set (HEDIS) measures established by the National Committee for Quality Assurance (NCQA). 600M 110M Our progress