Introduction 42 2021 Sustainability Report A Modern, High-Performing Health System Our People and Culture Environmental Health Responsible Business Practices Performance Data Lowering drug costs Nearly two-thirds of U.S. adults take at least one prescription medicine, making the pharmacy the most frequently used touch point in all of health care. Three in 10 Americans say they haven’t taken their medicine due to costs. We understand drug costs matter to everyone — from those taking a generic medication to manage a chronic condition, to individuals accessing a novel therapy. We are actively working to reduce those costs across the system for consumers, employers and governments. Specialty drugs used to treat patients with complex conditions make up more than half of all drug costs and are projected to reach $505 billion in annual spending by 2023. Optum Rx is helping providers identify the best treatment regimen, weighing clinical and financial information to help customers have a better, more affordable experience across their medical and pharmacy benefits. Our commitment 55%+ of outpatient surgeries and radiology services among our members will be delivered at high-quality, cost-efficient sites of care by 2030 In 2021, close to 50% of outpatient surgeries and radiology services among all domestic people served were delivered at high-quality, cost-efficient sites of care. The percentage of care delivered at these sites for our commercial fully insured and self- funded members increased, while the percentage for members served through government programs remained relatively stable. We continue to increase the penetration and capabilities of our physician point-of-care tools to help guide patients to the most appropriate high-quality, low-cost care setting. We are also enhancing our consumer transparency digital tools to help members identify these settings and understand the relative cost impacts. Our progress 50% 55%