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22 Supplementary Table 1. Patient Age Sex Clinical status Time between Hydroxychloroquine Hydroxychloroquine serum Azithrom D0 D1 D2 D3 D4 D5 D6 (years) onset of treatment concentration µg/ml ycin symptoms and (day of dosage) treatment inclusion (days) 1 10 M Asymptomatic - No - No 31 NEG NEG NEG NEG NEG NEG 2 12 F Asymptomatic - No - No 26 ND 33 34 NEG 34 NEG 3 14 F Asymptomatic - No - No 26 31 23 22 27 NEG 26 4 10 M Asymptomatic - No - No 24 NEG 33 33 NEG NEG 32 5 20 M URTI 4 No - No 24 24 24 27 NEG 31 29 6 65 F URTI 2 No - No POS ND POS ND POS ND POS 7 46 M URTI Unknown No - No 28 ND ND ND 26 ND 30 8 69 M LRTI 2 No - No POS ND POS ND POS POS POS 9 62 F LRTI 10 No - No POS ND POS ND POS ND POS 10 66 F URTI 0 No - No POS ND POS ND ND ND POS 11 75 F URTI 3 No - No POS ND POS ND POS ND ND 12 23 F URTI 5 No - No ND ND POS ND POS ND ND 13 45 F URTI Unknown No - No POS ND POS ND POS ND POS 14 16 M URTI 2 No - No POS ND POS ND ND POS ND 15 42 F URTI 5 No - No ND ND ND POS ND POS ND 16 23 F URTI 6 No - No POS ND ND ND ND POS ND 17 44 F URTI 6 Yes 0.519 (D6) No 30 ND 29 26 32 26 31 18 54 M Asymptomatic - Yes 0.462 (D6) No 29 NEG NEG NEG NEG NEG NEG 19 25 M URTI 3 Yes 0.419 (D6) No 23 25 28 25 NEG NEG NEG 20 59 F Asymptomatic - Yes 0.288 (D4) No 30 NEG NEG NEG NEG NEG NEG 21 49 F URTI 1 Yes 0.621 (D6) No 34 27 19 16 34 24 22 22 24 F URTI 10 Yes 0.723 (D6) No 28 NEG 32 34 NEG NEG NEG 23 81 F LRTI 2 Yes 0.591 (D6) No 22 21 30 NEG 32 28 NEG 24 85 F LRTI 1 Yes 0.619 (D6) No 17 21 23 21 26 24 24 25 40 M URTI 3 Yes 0.418 (D6) No 22 ND 28 21 15 20 17 26 53 M URTI 5 Yes 0.515 (D6) No 27 28 32 31 NEG NEG NEG 27 63 F URTI 8 Yes 0.319 (D4) No 34 NEG 30 NEG NEG NEG NEG 28 42 F URTI 1 Yes 0.453 (D6) No 19 16 17 17 19 20 31 29 87 F URTI 5 Yes 0.557 (D6) No 25 30 NEG NEG NEG ND ND 30 33 M URTI 2 Yes 0.194 (D2) No 15 23 26 26 NF 32 32 31 53 F LTRI 7 Yes 1.076 (D6) Yes 28 31 34 NEG 34 NEG NEG 32 48 M URTI 2 Yes 0.57 (D6) Yes 23 29 29 NEG NEG NEG NEG 33 50 F LRTI 5 Yes 0.827 (D6) Yes 30 27 NEG NEG NEG NEG NEG 34 20 M URTI 2 Yes 0.381 (D6) Yes 27 31 29 NEG NEG NEG NEG 35 54 M LRTI 6 Yes 0.366 (D4) Yes 24 ND ND 29 NEG NEG NEG 36 60 M LRTI 4 Yes 0.319 (D4) Yes 29 31 31 NEG NEG NEG NEG URTI: upper tract respiratory infection, LRTI: lower tract respiratory infection, POS: positive PCR, NEG: negative PCR (CT value >35), ND: PCR not done

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