93 The Value Of Curing Rare Diseases Like Sickle Cell Anemia Is High Among precision therapies, gene editing medicines like CRISPR-Cas9 have the potential to cure rare genetic diseases such as Sickle Cell Disease (SCD). SCD is an inherited red blood cell disorder that affects more than 100,000 people in the US and 20 million people globally, primarily in Africa. Today, therapeutics account for ~16% of the total spent on treating SCD disease in the US, but they have done little more than manage symptoms, as the life expectancy of SCD patients is only 56% that of the general population. S SCD Healthcare Costs Over Average Patient Lifetime Reasonable Cost For Sickle Cell Disease Cure E PI Therapeutics Other Costs A R E $2.5 H $2.5 T N O I $2.0 $2.0 S I C E ns ns PR io $1.5 io $1.5 l l il il M $1.0 M $1.0 $0.5 $0.5 Other Costs $0.0 Therapeutics 1 3 5 7 9 11 13 15 17 19 21 23 25 27 29 31 33 35 37 39 41 43454749 51 53 $0.0 Age Current Direct Cost Quality of Life Years Gained* New Therapy Cost Forecast *Quality of Life Years Gained = Health Utility * Duration For Health Utility, 0 means dead and 1 means full health Data are as of December of 2023. Sources: ARK Investment Management LLC, 2024. This ARK analysis is based on a range of external sources, which may be provided upon request. Forecasts are inherently limited and cannot be relied upon. For informational purposes only and should not be considered investment advice or a recommendation to buy, sell, or hold any particular security. Past performance is not indicative of future results.