OUR PURPOSE PIONEERING SCIENCE PATIENTS OUR PEOPLE ENVIRONMENT COMMUNITY REPORTING 36 BIOGEN 2021 YEAR IN REVIEW PATIENTS Advancing health access and equity so patients can live healthier lives EXECUTIVE SUMMARY WORKING FEARLESSLY TO CHANGE LIVES The past two years have shined a bright light on the importance of health and the need for innovation and equity in healthcare. Biogen’s approach involves seeing each patient not as a profile, but as a person, and putting the diverse individuals we serve at the center of everything we do. Our commitment starts within, and in 2021 we offered a wide range of learning opportunities to share patient voices and emerging data with employees company wide. In 2021, Biogen’s international Patient Advocacy teams engaged with dozens of patient advocacy groups (PAGs) and with healthcare providers (HCPs) to listen, learn and provide relevant support, education and resources. We hosted six Alzheimer’s Disease Readiness Briefings with over 70 Alzheimer’s leaders from 60 PAGs; launched two new MS campaigns and a feature-length movie; and engaged the SMA community from virtual events to the creation of a new book for elementary school children. We also help connect HCPs with experts and information, such as through our 2021 biosimilars summit. We worked to expand access to medicine, with Early Access Programs (EAPs) in 40 countries. One example is our 2021 early access to tofersen to eligible SOD1-ALS patients (see below). Recognizing that stakeholders see pricing as a material ESG issue for Biogen, we took action on pricing for ADUHELM®, expanded access to MS and SMA therapies in China, and entered into SMA Risk Sharing Agreements in additional markets, with SPINRAZA® now having either a formal reimbursement, individual reimbursement or a Named Patient Program in 65 countries. There is an increasing focus on the social determinants of health, as well as health equity and access. In the past year, we have made tangible strides in our commitment to addressing inequities across the healthcare system. Key strategies include underserved and underrepresented patient engagement and education; increasing representation in clinical trials; expanding medical publications with data pertaining to underserved and underrepresented patients; engagement of key medical experts; and expanding access to our therapies. Believing that biology and technology should go hand in hand to better meet patient needs, while enabling more prevention-focused, affordable and equitable care, in 2021 we formed Biogen Digital Health, a global unit that aspires to transform patients’ lives and Biogen by making personalized and digital medicine in neuroscience a reality. Our digital health focus areas include digital biomarkers, personalized neurology, care pathway digital solutions for patients and HCPs, and digital therapeutics. Through our focus on patients and the people who support them, we’re driving solutions to advance equitable research, clinical care and patient empowerment, resolute in ensuring that all patients are better positioned to realize optimal health. Advocating for patients, engaging with healthcare professionals When facing neurological disease, patients and their families often have questions and need support that can go beyond medical therapies alone. Biogen’s Patient Advocacy team engages with PAGs to listen, learn and provide relevant support and resources for those living with disease. We also work closely with HCPs to advance disease education, providing timely information on Biogen therapeutic areas so they can best care for patients. Patient advocacy Through our long-term relationships with PAGs and other stakeholders, Biogen’s Patient Advocacy team ensures patients are at the center of everything we do. For example, our Patient Voice Series connects Biogen employees with patients to better understand critical issues such as affordability and access, and what matters most to those we’re striving to help. In 2021, we held several events, one of which inspired U.S. employee Jenn Gardella to bike across the U.S. to raise money for MS. Read Jenn’s story in the Our People section. We also work to explore ways to help patients and promote continuity of care in extraordinary circumstances, such as helping people impacted by the war in Ukraine. Þ READ MORE This not only motivates us to work fearlessly in patient-focused therapy development, it also inspires our ongoing engagement with more than 50 PAGs, healthcare professionals and other stakeholders in the disease areas we treat.