OUR PURPOSE PIONEERING SCIENCE PATIENTS OUR PEOPLE ENVIRONMENT COMMUNITY REPORTING 37 ADVOCATING FOR PATIENTS, ENGAGING WITH HEALTHCARE PROFESSIONALS BIOGEN 2021 YEAR IN REVIEW Alzheimer’s disease According to the World Health Organization, there are currently 55 million people living with Alzheimer’s disease and other types of dementia 1 . How we define Alzheimer’s disease has meaning on many levels – from the individual patient and doctors to the research community. In 2020 we hosted seven Alzheimer’s Disease Readiness Briefings with over 70 Alzheimer’s leaders from 60 PAGs as well as two Global PAG Steering Committees with nine leaders from the global advocacy community. The goal was to raise awareness and educate about strategic Alzheimer’s topics, better understand unmet needs and identify opportunities for collaboration. Þ LEARN MORE ABOUT THE BRIEFINGS In 2021 in the U.S., Biogen worked with the Alzheimer’s Foundation to launch the “More Time” campaign focused on families impacted by Alzheimer’s disease and wanting more time with their loved ones. The “More Time” campaign kicked off with full-page print ads in The Wall Street Journal and USA Today featuring open letters from Alzheimer’s Association CEO Harry Johns and including three personal stories from patients and loved ones. “More Time” generated considerable engagement, including more than 92 million impressions. Building on Biogen and Eisai’s global “It’s Time” campaign, we launched a campaign that includes a multilingual awareness video and patient stories from around the world, beginning with Brazil. The effort emphasizes the need for understanding for Alzheimer’s disease patients and the importance of early diagnosis. In Germany, we supported the development of the “White Book,” which provides facts on many aspects of Alzheimer’s disease, including epidemiology, diagnosis and current options and costs for treatment and care. It was authored by Alzheimer’s disease experts with input from payers, health economists, doctors’ association representatives and researchers. We also hosted four online dialogues about Alzheimer’s disease, with the participation of experts from politics, medicine and society addressing the patient perspective, medical implications, digital solutions and political challenges. MS Biogen has collaborated with PAGs including We Are III, Can Do MS, the MS Foundation, MS International Federation, European Multiple Sclerosis Platform, Shift.ms and MS News and Views to address issues facing MS patients. In 2021, we hosted a webinar with academic partners to share the latest research and MS guidelines related to COVID-19 vaccines. Multiple key U.S. PAGs participated, including the National MS Society, MS Association of America, MS Focus, Can Do MS, Accelerated Cure Project and the United Spinal Association – along with the European Multiple Sclerosis Platform. SPOTLIGHT Creatively raising SMA awareness Research and patient feedback show that the SMA community seeks additional education on the disease and treatment options, and that social media are key sources of SMA community information and driver of treatment decisions. We worked to ensure an accurate, compliant, appropriate and informative social media presence for SPINRAZA, tapping existing online patient communities and SMA patients who are social influencers. This includes a presence on Instagram, Facebook and various websites including The Mighty, a digital health community for people facing health challenges. These efforts can help raise awareness of SMA, engage with and offer relevant content for the SMA community, and bring the SPINRAZA experience to life through storytelling. One story featured Alyssa Jones and her 11-year-old daughter Lucy , diagnosed with SMA Type 2 as a toddler, and their journey marked by small wins. Another story comes from Juan Morales , a published author, who discusses his work as a life coach to help those who are struggling to keep a positive outlook. We continue to raise awareness of SMA across the world among various channels and audiences, including through forums and campaigns such as “Growing Towards the Sun” in China, a video series in Colombia, an original cartoon series demonstrating adult SMA in Brazil, and a second phase storytelling series in Argentina. 1. The World Health Organization. (2021, September 2). Dementia . Lucy has SMA Type 2. Pictured here with her brother, Lucas.