OUR PURPOSE PIONEERING SCIENCE 127 ESG DATA TABLE BIOGEN 2021 YEAR IN REVIEW PATIENTS OUR PEOPLE ENVIRONMENT COMMUNITY REPORTING Footnotes for 2021 ESG Data Table 1. Year of the result is based on the ranking publication year, which may use data from other time periods per the publication’s methodology. 2. The direct and indirect effects of the COVID-19 pandemic had a material impact on our environmental data in 2020, and, therefore, direct comparison to 2021 may not be applicable. Additional context related to the impact is provided in the Environmental Section of the Year in Review. 3. Environmental indicators include impacts from 100% of Biogen operations including owned and leased facilities. 4. Scope 1 values have been restated for calendar year 2019, while market based Scope 2 values have been restated for calendar year 2019 and 2020 in this 2021 publication based on methodology updates. 5. VCS-certified carbon offsets from New Bedford Landfill Gas to Energy project in Massachusetts. These offsets are considered abatement with avoided emissions, thus applicable to Carbon Neutral approach but not Net Zero. 2020 was the last year Biogen purchased carbon offsets as part of our abatement strategy. 6. Scope 3 categories 9, 10, 11, 13, 14 and 15 were determined to be not applicable or negligible. 7. Waste generation at affiliate offices, excluding Weston, Massachusetts, is considered de minimis and excluded. However, waste generation is estimated for the purposes of calculating Scope 3, Category 5 emissions. During 2021, waste generated in operations continued to decline because of operational impacts due to the COVID-19 pandemic. 8. Due to a decline in business travel and employee commute due to the COVID-19 pandemic, emissions from Scope 3, Categories 6 and 7 are minimal compared to normal operating conditions. In 2020, we added impacts from employees working from home to more accurately estimate these impacts. 9. The Scope 3 intensity increased from 2020 to 2021 because overall revenue declined. 10. Fleet carbon efficiency for 2020 is reduced compared to normal operating conditions due to a decline in business travel during the COVID-19 pandemic; the carbon impact associated with the fleet from 2019 to 2021 decreased by 4%. 11. Renewable energy certificates retired include bundled and unbundled Green-e certified Renewable Energy Certifications, Guarantees of Origin, J-Credits, Australian RECs I-RECs to match Biogen’s electricity usage in the U.S./Canada, Europe, Japan, Australia and South America/China/Mexico/United Arab Emirates, respectively. 12. RE100 member Biogen achieved 100% renewable electricity (as defined by RE100) across 30 of the markets in which it operates. 13. Percent of major sites assessed for water withdrawal using a context-based methodology. Fair, just and proportionate share of locally available renewable supplies is defined as a ratio of less than 1.0 using the Center for Sustainable Organization’s Corporate Water Gauge tool, a context-based water metric. 14. Data reflect percentage of reclaimed water on-site, harvested rainwater and municipal grey water compared to total water use. 15. All applicable waste disposal methods are included; no waste is disposed of by other or unknown methods. 16. Data include non-hazardous waste generated by Biogen operations (e.g., non-hazardous solid waste and trucked off wastewater). Waste derived from construction and demolition debris, incinerator ash and other contractor activities is not included. 17. All non-hazardous waste with energy recovery is generated by incineration. 18. For 2021, 1,361 metric tons of waste are incinerated for energy recovery, and 6 metric tons are incinerated without energy recovery. 19. During 2021, no hazardous waste was destroyed via incineration. 20. Social indicators cover 100% of permanent employees unless otherwise noted. 21. Includes all grants awarded by the Biogen Foundation exclusive of the Biogen Foundation’s Employee Matching Gifts Program. In 2021, Biogen continued funding grants related to the committed $10 million to support global response efforts and communities around the world impacted by the COVID-19 pandemic. 22. Total in foundation grants is inclusive of STAR initiative investment. 23. Through our matching gifts program, employees donated more than $2 million to organizations around the world, giving particularly generously to address crisis situations, including the situation in Afghanistan and the COVID-19 spike in India. 24. Corporate Grants and Sponsorships includes Global Medical Grants and Patient Education Grants, General Grants, Infrastructure Grants, Fellowships and Sponsorships. 25. 10,312 hours were performed during paid working hours, assuming 8 hours per employee for each of the 1,289 employee respondents. Total monetary value of contributions associated with Biogen Grants, Sponsorships, in-kind and Community Labs, as well as the Biogen Foundation: $80 million cash contributions. 26. The STAR Initiative is a coordinated funding strategy designed to help catalyze the development of local science, technology, engineering and mathematics (STEM) ecosystems in Cambridge, Massachusetts, and Somerville, Massachusetts. STAR stands for Science, Teacher support, Access and Readiness and is intended to strengthen and support the educational landscapes in these cities by helping increase access to STEM resources and opportunities for students most underrepresented in STEM college or career pathways. 27. In 2021, minority-owned suppliers accounted for 19% of the diversity spend (2% of all Biogen supplier spending). 28. Women in management percentage is inclusive of all management levels, consisting of manager+ level employees. 29. Revenue generating functions include Pharmaceutical Operations & Technology, Commercial and Research & Development. 30. Demographics are inclusive of all management levels, consisting of manager+ level employees. 31. Racial and ethnic demographics that do not apply are excluded. 32. For 2017, our employee satisfaction metric was based on the question “Are you proud to work for Biogen” in our annual people survey. For 2018-2019, the employee satisfaction question was changed to “How happy are you working at Biogen?” Using total engagement score from June 2020 survey: “I would recommend Biogen as a great place to work” and “How happy are you working at Biogen?” The ‘strongly agree’ and ‘agree’ responses are included in the reported activity engaged percentile. 33. In August 2019 Biogen completed the sale of all outstanding shares of its subsidiary that owned its biologics manufacturing operations in Hillerød, Denmark, to FUJIFILM Corporation. The 2019 total turnover data do not include the 800 employees who continued employment under Fujifilm ownership. 34. The gender pay assessment includes data covering all permanent global employees adjusted for the number of females and males at each level within the organization for base compensation only. The ratio is calculated by averaging the mean base pay for women in the stated role in comparison to the mean base pay of men in a similar role. We also assess our gender pay gap for employees in the U.K. Our latest report can be found here . 35. Includes permanent and contracted employees, excludes contractors (e.g., construction, janitorial, food services). 36. Industry composed of 15 leading pharmaceutical company peers. 37. Contractor DACR: Includes construction-related contractors only. 38. Fleet insurance provided was changed in 2020 resulting in change in definition of collision.