OUR PURPOSE PIONEERING SCIENCE COMMUNITY REPORTING 79 BIOGEN 2021 YEAR IN REVIEW PATIENTS OUR PEOPLE ENVIRONMENT ENVIRONMENT Biogen is taking bold action on the deeply interrelated issues that define our time: Climate, health and equity EXECUTIVE SUMMARY 2021 HIGHLIGHTS The climate crisis is a health crisis: in addition to the well- documented climate impacts associated with greenhouse gases, research shows that fossil fuel emissions are a leading cause of death globally, claiming 9 million lives each year and potentially harming brain health. As a pioneer in neuroscience, Biogen aims to be a catalyst for positive change through Healthy Climate, Healthy Lives™, a 20-year, $250 million commitment to advance climate, health and equity. In 2021, Biogen advanced efforts to go beyond net zero and eliminate all fossil fuels from operations, beginning with zero emissions by 2040 – the first Fortune 500 company to set that ambitious Science Based Targets initiative (SBTi)-approved goal. To further our commitment to 1.5°C climate science in 2022, Biogen has set a net zero target of 2045 across the entire value chain, guided by SBTi’s net zero corporate standard, and is currently seeking SBTi approval for this goal. With oversight from the Executive Team, corporate Board of Directors and functional leadership, as well as employee engagement at all levels, Biogen made good progress on Healthy Climate, Healthy Lives™ activities in 2021 including: – Transitioning to an all-electric vehicle (EV) fleet, with an EV program in 12 countries. – Performing comprehensive energy audits of our U.S. operations sites with a focus on phasing out scope 1 emissions by 2030. – Sustaining our 100% renewable electricity commitment. – Creating Sustainable Drug Development principles and integrating them into several critical stages of the development process. – Completing a My Green Lab pilot program in 14 R&D and Product Technology Development labs to make our science even more sustainable. – Continuing work to phase out plastic in secondary packaging, as well as completing a life cycle assessment of several products. – Collaborating with key suppliers and industry peers to amplify the impacts of Healthy Climate, Healthy Lives and work to decarbonize the pharmaceutical sector. – Engaging 14.7% of employees in climate-related benefits and programs at work, at home and in our communities. – Collaborating with global leaders, advancing the science of climate and health and working to influence climate policy to improve health outcomes, particularly for vulnerable populations. Key efforts are underway with the Harvard T.H. Chan School of Public Health, MIT, the World Economic Forum and the World Business Council for Sustainable Development, among others. Biogen also is sustaining our focus on water, waste and other environmental priorities, and is honored to be recognized for environmental leadership including: – Climate Leadership Conference’s Climate Leadership Award for Biogen CEO Michel Vounatsos. – 2021 winner of U.S. Chamber of Commerce Foundation’s Best Sustainability Program. – Top Sustainability Advocate Award in Asia for Biogen Japan. The Lancet Countdown called climate change “the biggest global health threat of the 21  century. ” st