OUR PURPOSE PIONEERING SCIENCE COMMUNITY REPORTING 80 BIOGEN 2021 YEAR IN REVIEW PATIENTS OUR PEOPLE ENVIRONMENT Advancing Healthy Climate, Healthy Lives™ Striving for fossil fuel free operations According to a Lancet report , long-term exposure to air pollution – even in concentrations below U.S. national standards – is associated with an increased risk of Alzheimer’s disease. This is a risk factor that society can change by reducing our reliance on fossil fuels, which also contribute to the climate crisis. In line with our participation in the U.N. Business Ambition for 1.5°C, Biogen is working to transform our operations to enhance efficiency, speed electrification and eliminate fossil fuel emissions by 2040. Decarbonizing our facilities and processes The 2022 climate report from the Intergovernmental Panel on Climate Change (IPCC) shows that the climate crisis is accelerating, with deaths from floods, droughts and storms already 15 times higher in vulnerable regions. The authors state that to avoid mounting loss of life, biodiversity and infrastructure, ambitious, accelerated action is required, along with rapid, deep cuts in greenhouse gas (GHG) emissions. Biogen is taking action to eliminate our use of fossil fuels, beginning with zero emissions by 2040. From 2019 to 2021, we achieved a 6% decrease in our direct GHG emissions from sources that are controlled and/or owned by Biogen. In that same timeframe, we decreased our emissions of carbon monoxide (CO) by 45% and nitrogen oxides (NO X ) by 22%, while ensuring there were no significant increases in emissions of sulfur dioxide (SO 2 ), volatile organic compounds (VOCs) or PM 2.5 air pollution, which can have harmful health impacts. Our renewable electricity strategy includes onsite generation, reducing demand through efficiencies, direct purchase of green power and virtual power purchasing agreements (VPPAs). This marks a shift toward more impactful purchasing, actively exploring direct purchasing and options for VPPAs that can help expand the market for renewable energy. Where necessary, Biogen also purchases unbundled renewable energy credits (RECs). In 2021, Biogen sustained our 100% renewable electricity commitment. Our 2021 progress includes: – Sourcing directly from a hydropower plant for our site in Solothurn, Switzerland, which we began last year. – Continuing to source hydropower directly from the Harriman Hydro Plant in Readsboro, Vermont to power our corporate headquarters in Cambridge, Massachusetts. – Beginning the VPPA process in 2021, with the intention to execute in 2022. Renewable electricity initiatives like direct purchase of green power, virtual power purchasing agreements, and unbundled renewable energy credits will help Biogen reach its goal of eliminating fossil fuel emissions by 2040.