OUR PURPOSE PIONEERING SCIENCE COMMUNITY REPORTING 86 ADVANCING HEALTHY CLIMATE, HEALTHY LIVES™ BIOGEN 2021 YEAR IN REVIEW PATIENTS OUR PEOPLE ENVIRONMENT Understanding of potential link between air pollution and dementia It is well-established that air pollution is detrimental to human health. What has been less clear is the potential connection between air pollution and dementia, although studies on the subject have proliferated in recent years. In 2021, Biogen worked with the Harvard T.H. Chan School of Public Health NIEHS Center for Environmental Health to conduct the most comprehensive systematic meta-analysis to date on air pollution and dementia. Presented at the 2022 American Academy of Neurology conference, the analysis found that the data highly suggest small air pollution particles (PM 2.5 ) are a risk factor for dementia. The Harvard meta- analysis includes studies across nine countries on three continents and, for the first time, includes prospective cohort studies which follow participants over time. The results have been submitted for peer review and will be shared at the American Academy of Neuroscience (AAN) 2022 annual meeting. “The data are clearly pointing toward PM 2.5 playing a role in risk of dementia,” said senior author Professor Marc Weisskopf, Harvard T.H. Chan School of Public Health. “More data would clearly still be helpful, in particular, studies with methods that actively assess all study participants. Some key questions persist. For example, exactly when these exposures are most relevant is still unclear; and identifying biological mechanisms underlying these relations would be very useful.” Building an advanced new climate-health model We also are working to use existing data in new ways to spur insights and action. Notably, in 2021, we announced an enhanced collaboration with the MIT Joint Program on the Science and Policy of Global Change and the Technology and Policy Program to develop a state-of-the-art integrated model of how various climate actions impact public health. A new model has been constructed to enable scenario development, and new metrics and approaches for model evaluation are being tested. This new tool is designed to give policymakers and other stakeholders a game-changing tool to make data-driven decisions on which climate actions can deliver the greatest public health benefits, particularly for vulnerable communities. By incorporating the economic benefits of The data are clearly pointing toward PM 2.5 playing a role in risk of dementia.” Marc Weisskopf Professor, Harvard T.H. Chan School of Public Health positive health, the model can enable policymakers, companies and other stakeholders to set new climate-health targets. The model was previewed at the Forum of the MIT Joint Program on the Science and Policy of Global Change in March 2022. To help translate targets into action, in 2021, Biogen became the first biotech company to join the MIT Climate and Sustainability Consortium, a leading group of 13 global businesses, including Accenture, Apple, Verizon and IBM, collaborating to advance climate innovations. We also are continuing our work with the Harvard T.H. Chan School of Public Health Center for Climate, Health, and the Global Environment (C-CHANGE) and Americares to help under-resourced healthcare clinics better address climate risks. Þ LEARN MORE HERE Advocating for action In a joint statement , 230 medical journals globally reported that “the greatest threat to global public health is the continued failure of world leaders to keep the global temperature rise below 1.5°C.” Biogen is engaging with global leaders and advocating for action. For example, Biogen CEO Michel Vounatsos serves on the World Economic Forum (WEF) Alliance of CEO Climate Leaders and, in 2021, we expanded our involvement, becoming a founding member of the WEF Alliance for Clean Air. The World Business Council for Sustainable Development’s (WBCSD) Healthy People, Healthy Business project – a cross-sectoral coalition of 23 leading companies, co-chaired by Biogen and Solvay – has been working closely with the scientific community to better understand the 18% of Biogen’s top 80% of suppliers, by spend, have set or pledged to set SBTi- approved targets