OUR PURPOSE PIONEERING SCIENCE COMMUNITY REPORTING 87 PROMOTING ENVIRONMENTAL SUSTAINABILITY BIOGEN 2021 YEAR IN REVIEW PATIENTS OUR PEOPLE ENVIRONMENT SPOTLIGHT Collaborating for change at COP26 Biogen had a visible presence at COP26, the 26 th United Nations Climate Conference in 2021, which brought over 30,000 leaders together to collaborate on climate action. Biogen worked with the United Nations to host a panel entitled “Promoting Climate, Health & Equity is Everyone’s Business,” which explored the latest science on climate change and the way it impacts human health, particularly for vulnerable populations. The U.K. National Health Service (NHS) made a historic commitment to become the first national health system to set a net zero goal for 2040. We are proud that Biogen’s CEO Michel Vounatsos is part of the NHS International Leadership Committee to advise on this ambitious vision. This endeavor involves commitments to net zero carbon emissions from key NHS suppliers, including Biogen, as well as leaders such as the CEOs of Apple, GSK, Novo Nordisk and Unilever, among others. A small increase in exposure to [air pollution] leads to a large increase in COVID-19 death rate. In the U.S., Black Americans are subjected to higher levels of air pollution than white Americans regardless of their wealth, according to the EPA. Harvard T.H. Chan School of Public Health This work has involved dialogue during Climate Week 2021 , a dozen workshops and other collaborative efforts to identify practical paths that businesses from all sectors can take in leading efforts that raise awareness of this issue, build new partnerships and integrate health more prominently into decision-making to drive co-benefits for people and planet. We expect this work to result in a report that can guide businesses and serve as a platform for advocacy and accelerated, ambitious action on climate, nature and equity with a view to COP27 in November of this year. Biogen also publicly supported multiple open letters and position statements calling for accelerated action in line with a 1.5°C temperature target. Most recently, we engaged with advocacy groups, government and energy suppliers to voice our strong support for a more rapid expansion of EV infrastructure in North Carolina. Low Medium High 0 20 40 60 80 100 0 20 40 60 80 100 0.000 0.005 0.010 0.015 0.020 0.025 0.030 0.035 0.040 One application of the tool being developed with MIT (pictured) is a combined metric of health risk from poor air quality (exposure to particulate matter) and temperature stress, weighted by the fraction of the population below the poverty level in each county. This is helping to rapidly identify “hotspots” where climate and health-related risks are combining in areas in which people have fewer resources to adapt to the resultant harm. A NEW MODEL OF CLIMATE AND HEALTH RISKS relationship between the environment and human health, as well as the urgent actions needed to secure a livable future. The work of the coalition explores how business can: – Embed a culture of health and well-being at the workplace. – Support healthy consumer lifestyles. – Build resilient and accessible health systems. – Accelerate action on climate, nature and equity informed by planetary health science.