OUR PURPOSE PIONEERING SCIENCE PATIENTS OUR PEOPLE ENVIRONMENT COMMUNITY REPORTING 51 ADVANCING HEALTH ACCESS AND EQUITY BIOGEN 2021 YEAR IN REVIEW In 2021, we joined the Association of Clinical Research Professionals (ACRP) as part of ACRP Partners in Workforce Advancement™, a multi- stakeholder initiative to expand the diversity of the clinical research workforce, and to set and support standards for workforce competence. We also joined the Society of Clinical Research Professionals to contribute to DE&I initiatives and best practices at the site level. New questions and new tracking To engage more underserved and underrepresented populations in clinical trials, stakeholders must address legacies of mistrust, language barriers and unconscious bias in the medical community. Biogen’s Medical Research Review Committee is working to enhance diversity through sponsored research agreements and investigator- initiated trials. In 2021 we added new questions to research proposal questionnaires to better gauge investigators’ plans regarding clinical trial diversification. We also launched an Internal Participant Demographic Distribution Dashboard to be transparent and consistent in tracking and measuring the demographic distribution of our participants across programs and studies and to compare directly to targets. We’re also members of Tufts Center for Study of Drug Development’s Investigative Site Diversity Initiative to benchmark diversity and disparities among clinical trial sites. Community Advisory Board Formed in 2020, our Community Advisory Board (CAB) consists of patient advocates from underserved and underrepresented communities who co-develop honest and transparent educational assets for patients, HCPs and clinical trial sites. In 2021, the CAB expanded to include representation from Asian American, Pacific Islander and Native American communities in addition to Black, African American, Hispanic and Latino members. With the input and insights of the CAB, we created a suite of educational assets for patients, HCPs and clinical trial sites to discuss the importance of diversity in clinical trials. The CAB has also advised on the Alzheimer’s disease program and study designs, as well as the development of Biogen Trial Link, our website to learn more about and find a clinical trial. Our CAB received the 2021 Global Pharma Patient Champion Award. Bringing clinical trials to underrepresented and underserved populations In partnership with NMQF, we launched the Clinical Trial Index and Clinical Trial Learning Community (CTLC), which uses U.S. heat maps of Medicare/Medicaid beneficiary data by patient demographics mapped against clinical trial site locations, to identify appropriate sites in key locations. CTLC launched as a virtual space for local stakeholders and subject matter experts to integrate routines in local care networks to increase underrepresented and underserved population participation in clinical trials. In addition, Boston Medical Center was selected for our TOPAZ-1 study, which is focused on treatments to help patients with active systemic lupus erythematosus (SLE). For TOPAZ-1, enrollment targets have been set that reflect the prevalence of SLE in Black, African American, Hispanic or Latino communities. Globally, our Australia HORIZONS project is bringing clinical trials to remote and rural areas with lack of access. In the U.K., we are conducting research into the landscape of underserved and underrepresented patient populations and presented a socioeconomic data poster at the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS). Expanding medical publications with data pertaining to underserved and underrepresented patients  Medical publications and academic journals also represent an important part of our strategy. In 2021, we provided more than 30 publications with information on MS and SLE data gaps including real-world evidence data. In Neurology Reviews , Wanda Castro-Borrero, Global Head of MS Franchise, raised awareness of data gaps for LGBTQ+ MS patients. Þ READ WANDA’S PERSONAL STORY