OUR PURPOSE PIONEERING SCIENCE COMMUNITY REPORTING 92 PROMOTING ENVIRONMENTAL SUSTAINABILITY BIOGEN 2021 YEAR IN REVIEW PATIENTS OUR PEOPLE ENVIRONMENT Land and water use More than 90% of the impact to land use comes from the solid bleached board for cartons and trays and paper for patient inserts. More than 98% of the water consumption associated with these products relates to hydropower, which some Biogen sites use as a source of renewable electricity. Acting on new insights The team is carefully analyzing the data and developing an action plan, starting with areas with the greatest potential for positive impact. We have identified several potential areas to explore, including: – Accelerating goals for fossil fuel free energy – the greatest impact across the product lifecycle comes from energy use, which we are addressing via Healthy Climate, Healthy Lives™. This assessment can help us pinpoint areas of greatest concern and prioritize our investments to deliver the greatest climate and health benefits. – Reducing product materials – we are considering options for less environmentally impactful materials, where patient health and safety and regulations allow. For example, polypropylene has a 55% lower carbon footprint than acrylonitrile butadiene styrene (ABS) and 75% lower than polycarbonate. Where possible, we also could consider recycled plastic. We hope to design and secure approval for reusable therapy delivery mechanisms, such as the pen. This could have a meaningful impact, since using a device twice could effectively cut the carbon impact roughly in half. – Packaging to meet customer preferences and patient needs – importantly, we found that product multipacks don’t necessarily have lower impact than smaller packs. This information could help us engage with customers to elevate packaging options that meet their needs with a lower environmental impact. We also are exploring alternatives to bleached paper, lighter packaging materials and ways to use less packaging overall, which could improve the customer experience while advancing environmental goals. Approaches may include removing inner cartons from multipacks; considering recycled content; and reducing tray and carton weight to lower material, upstream transport, distribution and end-of-life impacts. 50% 45% Device materials Packing at supplier sites Device end of life Packaging material Distribution 14% 5% 17% 18% 40% 30% 20% 10% Analysis – Our product lifecycle