OUR PURPOSE PIONEERING SCIENCE COMMUNITY REPORTING 91 PROMOTING ENVIRONMENTAL SUSTAINABILITY BIOGEN 2021 YEAR IN REVIEW PATIENTS OUR PEOPLE ENVIRONMENT Analysis – Our product lifecycle Taking a science-based approach As part of the process, we engaged with Pure Strategies, an independent outside organization, to conduct an objective, science-based analysis. The team considered several key impact categories and used a standard methodology to assess impact across each product, delivery mechanism, packaging option and country. We assessed the impact per finished product and per dose. Key findings: Energy and packaging are key While some data analysis is ongoing, preliminary findings suggest we have two key opportunities for positive impact: reducing energy used in product production and reducing packaging. Climate impacts We found that just a few processes are the major contributors to both the carbon footprint of the products analyzed and air pollution. These include: – Energy to make solid bleached board for packaging, which includes the wood needed to make the board and the electricity to transform it. – Glass vial carbon footprint due to natural gas for energy production. – Materials for the devices, due to the energy needed to manufacture them and fossil fuels required for plastic parts. Air pollution The LCA also provided important insights into the key drivers of air pollution, which can impact human health: – All sulfur dioxide (SO 2 ) impact is from fuel burned to create energy. – The majority of NO X comes from a combination of solid bleached board for packaging, product parts and supplier energy use. Impact Category Description Methodology GLOBAL WARMING POTENTIAL Potential to cause climate change by the release of greenhouse gases. IPCC 2013 100-year LAND USE The amount of land transformed or occupied for a certain time. ReCiPe 2016 Midpoint (H) V1.04/ World 2010 WATER CONSUMPTION Amount of fresh water consumed. ReCiPe 2016 Midpoint (H) V1.04/ World 2010 NITROGEN OXIDES (NO X ) A measure of air pollution, these gasses contribute to the formation of smog, acid rain and ground level ozone. NO X typically result from combustion of fuels. Inventory data SULFUR DIOXIDE (SO 2 ) A measure of air pollution, SO 2 causes acid rain and affects the respiratory system. It typically results from burning fossil fuels by power plants. Inventory data CUMULATIVE ENERGY DEMAND (TOTAL) Direct and indirect use of energy. Cumulative Energy Demand V1.11 CUMULATIVE ENERGY DEMAND, NON-RENEWABLE FOSSIL ENERGY Direct and indirect use of non- renewable fossil-based energy. Cumulative Energy Demand V1.11