OUR PURPOSE PIONEERING SCIENCE 142 GRI CONTENT INDEX BIOGEN 2021 YEAR IN REVIEW PATIENTS OUR PEOPLE ENVIRONMENT COMMUNITY REPORTING GRI indicator Reporting Requirements 2021 Response Alignment SDG 303–4 a. Total water discharge to all areas in megaliters, and a breakdown of this total by the following types of destination, if applicable: • Surface water. • Groundwater. • Seawater. • Third-party water, and the volume of this total sent for use to other organizations, if applicable. b. A breakdown of total water discharge to all areas in megaliters by the following categories: • Freshwater (≤1,000 mg/L Total Dissolved Solids). • Other water (>1,000 mg/L Total Dissolved Solids). c. Total water discharge to all areas with water stress in megaliters, and a breakdown of this total by the following categories: • Freshwater (≤1,000 mg/L Total Dissolved Solids). • Other water (>1,000 mg/L Total Dissolved Solids). d. Priority substances of concern for which discharges are treated, including: • How priority substances of concern were defined, and any international standard, authoritative list or criteria used. • The approach for setting discharge limits for priority substances of concern. • Number of incidents of non-compliance with discharge limits. e. Any contextual information necessary to understand how the data have been compiled, such as any standards, methodologies and assumptions used. Additional requirements for compiling: 2.3 When compiling the information specified in Disclosure 303-4, the reporting organization shall use publicly available and credible tools and methodologies for assessing water stress in an area. Environment – 2021 Year in Review ESG Data Table – 2021 Year in Review [2021 CDP Water Security disclosure] 303–5 a. Total water consumption from all areas in megaliters. b. Total water consumption from all areas with water stress in megaliters. c. Change in water storage in megaliters, if water storage has been identified as having a significant water- related impact. d. Any contextual information necessary to understand how the data have been compiled, such as any standards, methodologies and assumptions used, including whether the information is calculated, estimated, modeled or sourced from direct measurements, and the approach taken for this, such as the use of any sector-specific factors. Environment – 2021 Year in Review ESG Data Table – 2021 Year in Review [2021 CDP Water Security disclosure]