OUR PURPOSE PIONEERING SCIENCE 141 GRI CONTENT INDEX BIOGEN 2021 YEAR IN REVIEW PATIENTS OUR PEOPLE ENVIRONMENT COMMUNITY REPORTING GRI indicator Reporting Requirements 2021 Response Alignment SDG 303–2 A description of any minimum standards set for the quality of effluent discharge, and how these minimum standards were determined, including: • How standards for facilities operating in locations with no local discharge requirements were determined. • Any internally developed water quality standards or guidelines. • Any sector-specific standards considered. • Whether the profile of the receiving body of water was considered. Environment – 2021 Year in Review ESG Data Table – 2021 Year in Review [2021 CDP Water Security disclosure] 303–3 a. Total water withdrawal from all areas in megaliters, and a breakdown of this total by the following sources, if applicable: • Surface water. • Groundwater. • Seawater. • Produced water. • Third-party water. b. Total water withdrawal from all areas with water stress in megaliters, and a breakdown of this total by the following sources, if applicable: • Surface water. • Groundwater. • Seawater. • Produced water. Third-party water, and a breakdown of this total by the withdrawal sources listed under a. and b. c. A breakdown of total water withdrawal from each of the sources listed in Disclosures 303-3-a and 303-3-b in megaliters by the following categories: • Freshwater (≤1,000mg/L Total Dissolved Solids). • Other water (>1,000mg/L Total Dissolved Solids). d. Any contextual information necessary to understand how the data have been compiled, such as any standards, methodologies and assumptions used. Additional requirements for compiling: 2.1 When compiling the information specified in Disclosure 303–3, the reporting organization shall use publicly available and credible tools and methodologies for assessing water stress in an area. Environment – 2021 Year in Review ESG Data Table – 2021 Year in Review