In January 2021, McKesson published its first-ever public statement on climate change, acknowledging the direct and significant impact climate change has on human health. In the statement, we also acknowledged that human action is related to the underlying environmental factors that contribute significantly to climate change and human health. These acknowledgments are what led us to embrace our responsibility and take additional action to protect our planet, sustain our business, and ultimately serve the health of patients and communities, some of whom are presently dealing with the impacts of climate-related issues and illnesses. While our Global Impact Organization, our ESG strategy and our climate change statement are new, for many years, teams across the enterprise have been implementing initiatives that mitigate our environmental impact. Climate change: risks and opportunities Climate change is a global problem that will require coordination and collaboration across geographies, industries and societies. It poses unique risks, but also presents opportunities for companies to adapt and increase the efficiency of their operations. The long-term effects of climate change are difficult to predict and may be widespread. The impacts may include physical risks (such as rising sea levels or increased frequency and severity of extreme weather conditions), social and human effects (such as population dislocations or harm to health and wellbeing), compliance costs and transition risks (such as regulatory or technology changes) and other adverse effects. The effects could impair, for example, the availability and cost of certain products, commodities and energy (including utilities), which in turn may impact the ability to procure goods or services required for business operations. For more information on how we manage climate- related risks and opportunities, please see our 2021 CDP Climate Change response. Introduction Stories Employees Access Equity Climate Operations >Table of Contents | 38 FY21 Impact Report

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