156 3D Printing Has Played A Role In Medical Breakthroughs In fewer than 24 hours after identifying the donor, Across a range of surgeries, 3D printed tools, guides, and models Materialise 3D printed pivotal surgical tools and guides increased performance, as measured by surgical accuracy and used in the world’s first eye transplant. Speed to operation results, by ~40-50% and reduced operating time on average by is critical to preserving donor tissue deprived of blood ~30%. supply. During Surgeries, 3D Printed Tools, Guides, and Models Shorten Time And Improve Accuracy Preoperative Planning +/- Standard Error G Surgical Tool/Guide N I 80% T N I t R n 60% P e 3D m 40% e v o 20% r p m 0% I t n -20% e c r Pe-40% -60% Donor Performance Time Patient Note: Time Savings and Accuracy Improvements Provided by 3D Printed Surgical Guides and Preoperative Planning Aides: bars represent the average percent improvement in time or performance as described in Bergmann et al. 2017 and Woodard et al. 2019, N=6-9 for each sample group. Error bars represent +/- standard error. The above analysis was conducted across medical fields; however, oral maxillofacial surgery and musculoskeletal studies were the most prevalent. Sources: ARK Investment Management LLC, 2024. This ARK analysis is based on a range of underlying data from external sources, including Diment et al. 2017, Meara et al. 2015, and Dobson 2020 as of January 17, 2024, which may be provided upon request. Forecasts are inherently limited and cannot be relied upon. For informational purposes only and should not be considered investment advice or a recommendation to buy, sell, or hold any particular security. Past performance is not indicative of future results.