2021–2022 GRI CONTENT INDEX The American Express 2021–2022 ESG Report references the Global Reporting Initiative (GRI) Standards: Core Option. In addition, we included disclosures from the Financial Services Sector Supplement. The following index outlines the location of the information required for each GRI disclosure. While most information is found in this report, other primary sources referenced include: 2021 Annual Report on Form 10-K , 2022 Proxy Statement , American Express website , and 2021 CDP Climate Change Response . Code GRI Disclosure Reference/Location General Disclosures GRI 2: General Disclosures (2021) 2-1 Organizational Details American Express Company 200 Vesey Street New York, NY 10285 Form 10-K Item 1 2-2 Entities included in the organization’s sustainability reporting 2021–2022 ESG Report: About This Report on page 3, Form 10-K Item 1 2-3 Reporting period, frequency and contact point • January 1, 2021–December 31, 2022. In some cases, we share highlights from programs and initiatives that were launched in 2022 to provide more up-to-date information to our stakeholders. • Frequency: Annual • Report Published: July 2022 • Contact: [email protected] 2-4 Restatements of information There are no restatements of information from prior periods in the 2021–2022 ESG Report. 2-5 External assurance We assure report content through an internal review process, including executive oversight of subject matter reviews and validation. Apex Companies, LLC (Apex) was engaged to conduct an independent verification of the energy consumption and greenhouse gas emissions reported by American Express for the calendar year 2021. 2021–2022 ESG Report: Supporting Data: Limited Assurance Statement of GHG Emissions on page 100. 2-6 Activities, value chain, and other business relationships Form 10-K Item 1 2-7 and 2-8 Employees • As of December 31, 2021, American Express employed approximately 64,000 colleagues, with approximately 22,000 in the United States and approximately 42,000 colleagues outside the United States • 2021–2022 ESG Report: Promoting Diversity, Equity & Inclusion: Backing Our Colleagues on pages 24-31 • Form 10-K Item 1 2-9 Governance structure and composition 2021–2022 ESG Report: ESG Governance on pages 76-88, 2022 Proxy Statement on pages 4-27 2-10 Nomination and selection of the highest governance body 2022 Proxy Statement on pages 4, 14-20 INTRODUCTION PROMOTING DE&I ADVANCING CLIMATE SOLUTIONS BUILDING FINANCIAL CONFIDENCE OUR ESG GOVERNANCE & OPERATING RESPONSIBLY SUPPORTING DATA OUR COMMITMENT TO ESG 114