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2021 ESG Report INTRODUCTION About This Report Fifth Third Supports Key Sustainability Initiatives Refer to our Investor Relations webpage for our SASB, GRI, SCM and UN Global Compact indices, as well as our latest TCFD Report. Fifth Third’s 2021 ESG report aims to provide transparency into how we activate our purpose: to improve the lives of our customers and the well - being of our communities. Since our 2019 ESG report three years ago, we have been reporting in accordance with the SASB Standards sustainable industry classifcation system for Commercial Banks, Consumer Finance and Mortgage Finance. In addition, we have been reporting on Global Reporting Initiative Standards’ core option, which includes general disclosures as well as topic-specifc disclosures relevant to Fifth Third. In February, we published our second TCFD Report to continue disclosing our progress in our climate journey. We also benchmark our strategy against the United Nation’s Sustainable Development Goals. In our 2020 ESG Report, we expanded reporting to include the Stakeholder Capitalism Metrics recommended by the World Economic Forum. In 2022, Fifth Third signed on to the UN Global Compact, a voluntary initiative based on CEO commitments to implement universal sustainability principles and take steps to support UN goals. Fifth Third is committed to accuracy and transparency in this report. The ESG data governance process uses the three lines of defense methodology (see page 89 ) for accountability and managing risks. This includes certifcations from the content contributors who constitute the frst line of defense. The report is reviewed by legal and second line of defense functions and also is subject to review as part of the Company’s audit program (third line of defense). The report is reviewed and overseen through governance committees, including the ESG Disclosure Council, ESG Committee, Nominating and Corporate Governance Committee and the Board of Directors. Data in this report covers Jan. 1 through Dec. 31, 2021, unless otherwise noted, and the narrative may include updates in 2022, where applicable. The goals discussed in this report are aspirational. While we are committed to achieving them, we cannot guarantee or promise that these goals will be met. Statistics and metrics in these disclosures include estimates and may be based on assumptions. Further, some of the fgures in this report may be unaudited. This report uses certain terms, including “material” topics, to refect the issues of greatest importance to Fifth Third and our stakeholders. Used in this context, these terms are distinct from and should not be confused Contents with the terms “material” and “materiality” as defned by or construed in accordance with the securities laws or as used in the context of fnancial statements and reporting. This report is for general informational purposes only and does not constitute an ofer or sale of any securities issued by Fifth Third Bancorp. All such ofers and sales shall be made only pursuant to an efective registration statement fled by Fifth Third Bancorp with the Securities and Exchange Commission and a current prospectus. The information in this report shall not be deemed to be incorporated by reference in any fling under the Securities Exchange Act of 1934 or the Securities Act of 1933, except as shall be expressly set forth by specifc reference. Introduction Economic Environment Social Governance All information in this report is current as of the date of publication. We undertake no obligation to update the information in this report or otherwise notify you in the event that any views, opinions or facts stated in this report change or subsequently become inaccurate. This report is not comprehensive and contains only voluntary disclosures on important ESG topics. For that reason, this report should be read in conjunction with our 2021 Annual Report on Form 10-K and our Form 10-Q for the quarter ended March 31, 2022 (particularly the “Forward-Looking Statements” and “Risk Factors” sections of both flings) and 2022 Proxy Statement, all of which can be found on our Investor Relations website. 8

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