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2021 ESG Report ECONOMIC Sustainable Financial Performance and Business Strategy Strategic planning is a critical aspect of Fifth Third’s ability to generate sustainable value. The outcomes of the planning process guide the long-term priorities and investment focus of the Company. The strategic planning process is designed to deliver a shared understanding of our vision, objectives, tactics and target outcomes, while maintaining risk management excellence and strong governance mechanisms. That shared understanding spans our Board of Directors and management and our front-line staf, enabling efective governance and clarity of purpose on our strategic priorities. Clearl y defned strategic priorities, proactive balance-sheet management and ongoing discipline position us well for the future. Our key strategic priorities have not changed over the past several years, even through the pandemic. Contents Introduction Economic Environment Social Governance Sustainable Financial Performance ($ IN BILLIONS, EXCEPT PER SHARE DATA) RETURN ON AVERAGE COMMON EQUITY SCALE: 15% 12.8 13.9 14.5 13.1 6.4 2017 2018 2019 2020 2021 SCALE: $175.00BN 2017 2018 2019 2020 2021 102.66 104.92 121.37 162.95 148.03 AVERAGE DEPOSITS AVERAGE SCALE: $210.00BN ASSETS 2017 2018 2019 2020 2021 194.23 206.32 140.53 142.18 163.94 CASH DIVIDENDS PER COMMON SHARE 1.08 1.14 0.60 0.74 0.94 2017 2018 2019 2020 2021 SCALE: 1.25 8. 08.9 693 646.6 7 682.8 12.8 7 2017 2018 2019 2020 2021 COMMON SHARES OUTSTANDING SCALE: 750.0 NET CHARGE-OFF RATIO 0% SCALE: 1. 2017 2018 2019 2020 2021 6 .42 .10 0 5 5 .32 3 3 0. 0. 0 Fifth Third’s Strategic Priorities Accelerate our digital transformation, driving increased use of digital channels, experience and engagement. Invest to drive organic growth and proftability, deploying capital to strategic opportunities that drive increased loan and fee growth. Expand market share in key geographies, including the Southeast, Texas and California. Maintain discipline in our approach to expense, rate risk and credit risk management. 19

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