2021 CORPORATE RESPONSIBILITY REPORT I 79 References Page 25 1. Kaufman HW, Chen Z, Niles J, Radcliff J, Fesko YA. Changes in the number of US patients with newly identified cancer before and during the coronavirus disease 2019 (COVID-19) pandemic. JAMA Netw Open. 2020;3:e2017267. doi:10.1001/jamanetworkopen.2021.25681 2. Kaufman HW, Bull-Otterson L, Meyer WA, et al. Decreases in hepatitis C testing and treatment during the COVID-19 pandemic. Am J Prev Med. 2021;61(3):369-376. doi:10.1016/j.amepre.2021.03.011 3. Pinto CN, Niles JK, Kaufman HW, et al. Impact of the COVID-19 pandemic on chlamydia and gonorrhea screening in the U.S. Am J Prev Med. 2021;61(3):386-393. doi:10.1016/j.amepre.2021.03.009 4. Fragala MS, Kaufman HW, Meigs JB, et al. Consequences of the COVID-19 pandemic: reduced hemoglobin A1c diabetes monitoring. Popul Health Manag. 2021;24(1):8-9. doi:10.1089/pop.2020.0134 5. Cavallo J. How delays in screening and early cancer diagnosis amid the COVID-19 pandemic may result in increased cancer mortality: a conversation with NCI Director Norman E. ‘Ned’ Sharpless, MD. The ASCO Post. September 10, 2020. Accessed April 22, 2021. https://ascopost.com/issues/september-10-2020/how-delays-in- screening-and-early-cancer-diagnosis-amid-the-covid-19-pandemic-may-result-in-increased-cancer-mortality/ 6. Harris Poll of 2,050 US adults. November 10-12, 2020. Data on file. Quest Diagnostics, 2020. Page 26 1. Kaufman HW, Chen Z, Niles JK, Fesko YA. Changes in newly identified cancer among US patients from before COVID-19 through the first full year of the pandemic. JAMA Netw Open. 2021;4(8):e2125681. doi:10.1001/jamanetworkopen.2021.25681 2. Risk of dying from cancer continues to drop at an accelerated pace. American Cancer Society website. Published January 12, 2022. Accessed May 1, 2022. https://www.cancer.org/latest-news/facts-and- figures-2022.html 3. Cavallo J. How delays in screening and early cancer diagnosis amid the COVID-19 pandemic may result in increased cancer mortality: a conversation with NCI Director Norman E. ‘Ned’ Sharpless, MD. The ASCO Post. September 10, 2020. Accessed April 22, 2021. https://ascopost.com/issues/september-10-2020/how- delays-in-screening-and-early-cancer-diagnosis-amid-the-covid-19-pandemic-may-result-in-increased- cancer-mortality/ 4. Hauptman M, Niles JK, Gudin J, Kaufman HW. Individual- and community-level factors associated with detectable and elevated blood lead levels in US children: results from a national clinical laboratory. JAMA Pediatr. 2021;175(12):1252-1260. doi:10.1001/jamapediatrics.2021.3518 Page 27 1. Harris Poll of 505 primary care physicians. August 12-19, 2021. Data on file. Quest Diagnostics, 2021. 2. Kaufman HW, Gudin J, et al. Drug Misuse in America 2021: Physician Perspectives and Diagnostic Insights on the Drug Crisis and COVID-19. November 2021. Quest Diagnostics Health Trends® . Quest Diagnostics. Page 28 1. Centers for Disease Control and Prevention, National Center for Health Statistics. Underlying Cause of Death 1999-2017 on CDC WONDER Online Database, released December 2018. Data are from the Multiple Cause of Death Files, 1999-2017, as compiled from data provided by the 57 vital statistics jurisdictions through the Vital Statistics Cooperative Program. Reviewed March 2, 2022. Accessed March 31, 2022. 2. Mosca L, Benjamin EJ, Berra K, et al. Effectiveness-based guidelines for the prevention of cardiovascular disease in women—2011 update: A guideline from the American Heart Association. Circulation. 2011;123:1–20. Accessed May 1, 2022. https://www.cdc.gov/dhdsp/pubs/docs/science_in_brief_cvd_women.pdf 3. Rosamond WD, Chambless LE, Heiss G, et al. Twenty-two–year trends in incidence of myocardial infarction, coronary heart disease mortality, and case fatality in 4 US communities, 1987–2008. Circulation. 2012;125:1848–1857. 4. Virani SS, Alonso A, Benjamin EJ, et al. Heart disease and stroke statistics—2020 update: a report from the American Heart Association. Circulation. 2020;141(9); e139-e596. doi:10.1161/CIR.0000000000000757 Page 29 1. Richardson LC, Henley SJ, Miller JW, et al. Patterns and trends in age-specific black-white differences in breast cancer incidence and mortality – United States, 1999–2014. MMWR. 2016;65:1093–1098. doi:10. 15585/mmwr.mm6540a1 2. Shavers VL, Harlan LC, Stevens JL. Racial/ethnic variation in clinical presentation, treatment, and survival among breast cancer patients under age 35. Cancer. 2003;97(1):134-147. doi:10.1002/cncr.11051 Page 30 1. Taquet M, Geddes JR, Husain M, Luciano S, Harrison PJ. 6-month neurological and psychiatric outcomes in 236,379 survivors of COVID-19: a retrospective cohort study using electronic health records. Lance Psychiatry. 2021;8(5):416-427. Doi:10.1016/S2215-0366(21)00084-5. https://www.sciencedirect.com/science/article/pii/ S2215036621000845 2. Alzheimer’s Association. 2021 Alzheimer’s disease facts and figures. Accessed December 7, 2021. https://www.alz.org/media/Docments/alzheimers-facts-and-figure.pdf 3. Li Y, Schindler SE, Bollinger J, et al. Validation of plasma amyloid- β 42/40 for detecting Alzheimer disease amyloid plaques. Neurology. Online ahead of print, December 14, 2021. doi:10.1212/WNL.0000000000013211 4. Data on file. Quest Diagnostics, 2022. 5. Burnham SC, Fandos N, Fowler C, et al. Longitudinal evaluation of the natural history of amyloid- β in plasma and brain. Brain Commun. 2020;2(1)fcaa041. doi:10.1093/braincomms/fcaa041 6. Cummings J, Lee G, Zhong K, et al. Alzheimer’s disease drug development pipeline: 2021. Alzheimers Dement (N Y). 2021;7(1):e12179. doi:10.1002/trc2.12179 Page 55 1. McKenna K. High employee morale decreases turnover. [Re: Achievers Workforce Institute 2022 Engagement and Retention Report. ] Business News Daily (online). Updated April 15, 2022. https://www.businessnewsdaily.com/15272-employee-experience-engagement.html TABLE OF CONTENTS 2021 OVERVIEW COVID-19 RESPONSE PROMOTING A HEALTHIER WORLD CREATING AN INSPIRING WORKPLACE BUILDING VALUE REFERENCES